The Role of Tumor Necrosis Factor-α in N740eurogenic Inflammation of Migraine

Abstract

Migraine is a common chronic episodic brain dysfunction disorder with high prevalence and disability rates worldwide. It severely impacts patients’ quality of life and imposes a heavy socioeconomic burden. Neurogenic inflammation plays a pivotal role in migraine pathogenesis, with tumor necrosis factor-α (TNF-α) serving as a key inflammatory mediator involved in the disease process. Traditional Chinese Medicine (TCM) offers unique insights into migraine pathogenesis through concepts like meridians and qi-blood dynamics. Additionally, certain active components in Chinese herbal medicines demonstrate effects on TNF-α and migraine. Future drug development targeting TNF-α and integrated treatment strategies hold promise for breakthroughs in migraine management. Research combining TCM and Western medicine will further expand therapeutic possibilities, thereby improving treatment outcomes and quality of life for migraine sufferers.