Integrated Management of Psoriasis: From Targeted Biologics to Adjunctive Traditional Chinese Medicine Therapies

Abstract

Psoriasis is a chronic immune-mediated inflammatory skin disease. The advent of biologics has significantly improved treatment efficacy. However, with their increasing application, numerous drawbacks—such as adverse reactions, the generation of anti-drug antibodies, immune deviation, disruption of skin barrier function, and high recurrence rates after discontinuation—have limited their broader use. In the current era of biologics, Traditional Chinese Medicine (TCM) offers not only traditional advantages like synergistic effects, reduced adverse reactions, and lower relapse rates, but also features multi-angle, multi-target, and broad-spectrum therapeutic actions. Furthermore, it plays a significant role in the clinical management of psoriasis comorbidities.