Analysis of the Medication Rules of Chief Physician Tang Yuanshan in the Treatment of Chronic Cholecystitis and Hepatobiliary Qi Stagnation based on Data Mining Technology

Abstract

Objective: Through data mining methods, summarize and refine the medication patterns of Chief Physician Tang Yuanshan in treating chronic cholecystitis of liver and gallbladder qi stagnation type. Methods: The diagnosis and treatment information of traditional Chinese medicine (TCM) was analyzed by data mining method, and the medication rules of Chief Physician Tang Yuanshan in the treatment of chronic cholecystitis and hepatobiliary qi stagnation were explored. Results: 245 prescriptions were collected, including 149 traditional Chinese medicines, with a total frequency of medication use of 2, 917 times. The top 15 in descending order of frequency are Bupleurum, Pinellia ternata, Yam, Paeonia lactiflora, Magnolia officinalis, Aurantii fructus, Honey-fried licorice, Codonopsis pilosula, Money Plant, Yujin, Coix Seed, Licorice, Poria cocos, peony Bark, and dried tangerine peel. The statistics of the four natures of drugs show that cold-natured, neutral and warm-natured drugs are predominant. The statistics of the five flavors of drugs mainly focus on bitter drugs, sweet drugs and pungent drugs. The meridians of the drugs are mostly the lung, spleen, liver and stomach. The total frequency of drug classification is in the following order: tonifying deficiency, promoting diuresis and removing dampness, regulating qi, etc. It can be seen from the network diagram and association rules that there are 50 pairs of drug pairs with strong connection numbers. Five core combinations of drugs were extracted through cluster analysis. Conclusion: Chief Physician Tang Yuanshan treats CC hepatobiliary qi stagnation type with the basic treatment principles of soothing the liver and relieving gallbladder and regulating qi and relieving depression. The commonly used prescriptions are the addition and subtraction of the four inverse powders, the addition and subtraction of Bupleurum Shugansan, and the addition and subtraction of Xiao Chai Hu Tang. Commonly used drugs are Bupleurum chinensis, white peony, citrus aurantium, tulip, desmodium, yam, licorice, etc. If the abdomen is full, add magnolia bark and citrus aurantium; belching, vomiting plus ochre, banxia, bamboo; Those who are bitter and upset add peony skin; For those with gallstones, add desmodium, sea sand, chicken gold, etc.