Hyaluronic Acid versus Autologous Fat for Facial Ligament Augmentation: A Systematic Review of Contour Fixation Efficacy and Duration of Effect

Abstract

Objective: To systematically evaluate the clinical efficacy, duration of effect, and safety of hyaluronic acid (HA) and autologous fat injections for facial ligament reinforcement, so as to provide evidence-based basis for clinical treatment selection. Methods: In accordance with the PRISMA statement, databases including PubMed, Embase, and Cochrane Library were searched to include relevant randomized controlled trials (RCTs), cohort studies, and case series. Literature quality assessment and data synthesis and analysis were performed. Results: This review summarizes the quantitative differences in efficacy indicators (including improvement in ligament support, correction of facial ptosis, and aesthetic satisfaction) and duration of effect between the two materials. Key factors influencing efficacy and duration of effect were analyzed, and the incidence of complications was compared. Conclusion: The advantages and applicable scenarios of the two materials in facial ligament reinforcement are clarified, and the limitations of current research and future research directions are pointed out.