Research Progress of Traditional Chinese Medicine in the Prevention and Treatment of Myocardial Ischemia-reperfusion Injury by Regulating BNIP3 Pathway

Abstract

Myocardial ischemia-reperfusion injury (MIRI) is a major challenge in the treatment of cardiovascular diseases. The pathogenesis of MIRI is complex and involves a variety of signaling pathways and molecular mechanisms. In recent years, BNIP3 (Bcl-2/adenovirus E1B 19kDa protein-interacting protein 3), as a key molecule regulating mitochondrial function and apoptosis, has attracted more and more attention in MIRI. This article discusses the regulation of BNIP3 pathway, inhibition of over-activation of HIF-1a/BNIP3 signalaxis, fine regulation of mitophagy flow, inhibition of BNIP3 mediated mitochondrial pathway apoptosis, and anti-oxidation and anti-inflammatory effects, so as to aleviate MIRI.