Research Progress on Acupuncture Prevention and Treatment of Senile Depression

Abstract

Late-life depression, as a common emotional disorder, significantly affects the quality of life and physical and mental health of older adults. With the intensifying trend of population aging, the search for safe and effective interventions has become a key focus in clinical practice and research. Acupuncture, a traditional Chinese medical therapy, has demonstrated unique advantages in regulating emotions and improving cognitive function. This paper systematically reviews the research progress on acupuncture in the prevention and treatment of late-life depression, covering the theoretical foundations of traditional Chinese medicine, commonly used acupoints and point combinations, clinical research findings, mechanisms of action, and analyses of safety and adaptability. Studies have shown that acupuncture can exert antidepressant effects through multiple pathways, including modulation of neurotransmitters, enhancement of brain functional connectivity, and regulation of immune and endocrine systems. Moreover, it offers good safety and patient acceptability. Despite promising results, current research still faces limitations such as small sample sizes, insufficient mechanistic studies, and lack of standardized treatment protocols. Future studies should focus on multicenter, large-sample, long-term clinical trials to promote the standardization and personalization of acupuncture therapy. In conclusion, acupuncture holds broad prospects and research value in the prevention and treatment of late-life depression.