Research Progress on the Mechanisms of Zuo Gui Wan for Treating Diminished Ovarian Reserve

Abstract

Zuogui Pill is derived from Jing Yue Quan Shu (Jingyue’s Complete Works). It is mainly used for the deficiency of kidney Yin and its function is to nourishing the kidney and filling the essence. It has been used clinically for more than 400 years and is now commonly used in the treatment of osteoporosis, knee osteoarthritis and other diseases. In recent years, more and more studies have shown that Zuogui pill has a certain effect in the treatment of Diminished ovarian reserve (DOR). This article summarizes the mechanism of Zuogui pill in the treatment of DOR from the aspects of metabolomics evidence, network pharmacological target prediction, regulation of sex hormone levels, promotion of ovarian germ stem cell proliferation, improvement of oxidative stress, and promotion of ovarian angiogenesis. From the molecular mechanism, it is revealed that Zuogui pill has the effect of treating DOR. This study systematically reviews the basic research progress of Zuogui pill in the treatment of diminished ovarian reserve (DOR), points out the limitations of the existing experimental system and puts forward optimization strategies, so as to provide theoretical support for the in-depth mechanism exploration, clinical transformation and new drug research and development of DOR.