Observation of Clinical Efficacy and Effect of Blood Rheology in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Treated with Lung-cleansing and Blood-activating Formulae

Abstract

Objective: To investigate the clinical efficacy and effects of Qinglong and Blood-cleansing Formula combined with conventional Western medical treatment on patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with phlegm-heat interlude and blood stasis, and the effects of the formula on blood rheology and inflammatory response. Methods: Eighty-eight patients with AECOPD were divided into 44 cases each in the observation group and the control group according to the randomized numerical table method. The control group was given conventional treatment with western medicine, and the observation group was treated with the combination of the formula of clearing lung and activating blood on this basis. The course of treatment was 10 days. Before and after the treatment, we compared the TCM evidence points, blood rheology indexes (whole blood viscosity, plasma viscosity, erythrocyte rigidity index, etc.), inflammation indexes (WBC, NEU, CRP, SAA), coagulation function and arterial blood gas analysis between the two groups, and evaluated the clinical efficacy and safety. Results: After treatment, the TCM evidence points, blood rheology and inflammation indexes of the observation group were significantly improved compared with the control group (P<0.05), and the total effective rate of the observation group was 90.9%, which was higher than that of the control group, which was 72.7% (P=0.029). In terms of arterial blood gas, the increase in partial pressure of oxygen and decrease in partial pressure of carbon dioxide were more significant in the observation group (P<0.05). There was no abnormality in the safety indexes. Conclusion: The combination of lung-cleansing and blood-activating formula with conventional treatment of western medicine can significantly improve the clinical symptoms, blood rheological status and oxygenation function of AECOPD patients, and has good clinical application prospects.