Randomized Controlled Trial Comparing Preemptive Multimodal Analgesia vs. Placebo on Postoperative Pain Outcomes in Unilateral Lichtenstein Hernioplasty

Abstract

Pain management is crucial in surgical procedures to improve patient recovery and comfort. This study evaluates the effectiveness of preemptive intravenous (IV) paracetamol in reducing postoperative pain in patients undergoing unilateral open inguinal hernia mesh repair. Conducted as a randomized controlled trial, the study included 56 patients divided into two groups: Group A received IV paracetamol (15 mg/kg in 100 ml normal saline) before surgery, while Group B received a placebo (100 ml normal saline). Pain levels were assessed using the Visual Analog Scale (VAS) at multiple time intervals postoperatively. Results indicated that Group A experienced significantly lower pain scores at 24, 36, and 48 hours, with near-complete relief by 72 hours. Additionally, Group B required more standard and rescue analgesia compared to Group A. These findings suggest that preemptive IV paracetamol effectively reduces postoperative pain and the need for additional analgesics, making it a safe and beneficial option for pain management in hernia repair surgery. Further research may explore the use of alternative analgesics such as diclofenac for improved outcomes.