Research Progress of Inflammatory Biomarkers in Patients with Post-stroke Cognitive Impairment
DOI:
https://doi.org/10.53469/jcmp.2024.06(07).35Keywords:
Poststroke cognitive impairment, Inflammatory biomarkers, Ischemic strokeAbstract
Post-stroke cognitive impairment (PSCI) is a common complication of stroke, which seriously affects the quality of life of stroke survivors. Inflammatory response is considered to be an important link in the pathogenesis of PSCI. The neuroinflammatory response is activated, releasing more inflammatory factors, leading to a large number of neuronal apoptosis, and then inducing related cognitive dysfunction. Serum marker as an important index reflecting the state of inflammation, become one of the key breakthrough research PSCI pathomechanism. Therefore, this article mainly discusses the role of these markers in PSCI and its research progress, to promote the individualized treatment strategies to develop and improve patients' quality of life.
References
Ma Q, Li R, Wang L, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990–2019: an analysis for the Global Burden of Disease Study 2019[J]. The Lancet Public Health, 2021, 6(12): e897-e906.
MijajlovićM D, Pavlović A, Brainin M, et al. Post-stroke dementia – a comprehensive review[J]. BMC Medicine, 2017, 15(1): 11.
El Husseini N, Katzan I L, Rost N S, et al. Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association/American Stroke Association[J]. Stroke, 2023, 54(6).
Pollock A, St George B, Fenton M, et al. Top ten research priorities relating to life after stroke[J]. The Lancet Neurology, 2012, 11(3): 209.
HertzogC, KramerA F, WilsonR S, et al. Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced? [J]. Psychological Science in the Public Interest, 2008, 9(1): 1-65.
Munthe-Kaas R, Aam S, Saltvedt I, et al. Test Accuracy of the Montreal Cognitive Assessment in Screening for Early Poststroke Neurocognitive Disorder: The Nor-COAST Study[J]. Stroke, 2021, 52(1): 317-320.
Kim H, Seo J S, Lee S Y, et al. AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice[J]. Brain, Behavior, and Immunity, 2020, 87: 765-776.
Kliper E, Bashat D B, Bornstein N M, et al. Cognitive Decline After Stroke: Relation to Inflammatory Biomarkers and Hippocampal Volume[J]. Stroke, 2013, 44(5): 1433-1435.
Narasimhalu K, Lee J, Leong Y L, et al. Inflammatory Markers and Their Association with Post Stroke Cognitive Decline[J]. International Journal of Stroke, 2015, 10(4): 513-518.
RostN S, Brodtmann A, Pase M P, et al. Post-Stroke Cognitive Impairment and Dementia[J]. Circulation Research, 2022, 130(8): 1252-1271.
Oldenbeuving A W, De Kort P L M, Jansen B P W, et al. Delirium in the acute phase after stroke: Incidence, risk factors, and outcome[J]. Neurology, 2011, 76(11): 993-999.
Mijajlović M D, Pavlović A, Brainin M, et al. Post-stroke dementia – a comprehensive review[J]. BMC Medicine, 2017, 15(1): 11.
De Haan E H, Nys G M, Van Zandvoort M J. Cognitive function following stroke and vascular cognitive impairment[J]. Current Opinion in Neurology, 2006, 19(6): 559-564.
Pluta R, Januszewski S, Czuczwar S J. The Role of Gut Microbiota in an Ischemic Stroke[J]. International Journal of Molecular Sciences, 2021, 22(2): 915.
Casolla B, Caparros F, CordonnierC, et al. Biological and imaging predictors of cognitive impairment after stroke: a systematic review[J]. Journal of Neurology, 2019, 266(11): 2593-2604.
Petrone A B, Eisenman R D, Steele K N, et al. Temporal dynamics of peripheral neutrophil and lymphocytes following acute ischemic stroke[J]. Neurological Sciences, 2019, 40(9): 1877-1885.
Gattringer T, Pinter D, Enzinger C, et al. Serum neurofilament light is sensitive to active cerebral small vessel disease[J]. Neurology, 2017, 89(20): 2108-2114.
Palmqvist S, Janelidze S, Quiroz Y T, et al. Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders[J]. JAMA, 2020, 324(8): 772.
Mun K T, Hinman J D. Inflammation and the Link to Vascular Brain Health: Timing Is Brain[J]. Stroke, 2022, 53(2): 427-436.
GrauA J, Buggle F, Becher H, et al. Recent bacterial and viral infection is a risk factor for cerebrovascular ischemia: Clinical and biochemical studies[J]. Neurology, 1998, 50(1): 196-203.
Breton A, Casey D, Arnaoutoglou N A. Cognitive tests for the detection of mild cognitive impairment (MCI), the prodromal stage of dementia: Meta‐analysis of diagnostic accuracy studies[J]. International Journal of Geriatric Psychiatry, 2019, 34(2): 233-242.
Califf R M. Biomarker definitions and their applications[J]. Experimental Biology and Medicine, 2018, 243(3): 213-221.
Tian Z, Ji X, Liu J. Neuroinflammation in Vascular Cognitive Impairment and Dementia: Current Evidence, Advances, and Prospects[J]. International Journal of Molecular Sciences, 2022, 23(11): 6224.
Lechtenberg K J, Meyer S T, Doyle J B, et al. Augmented β2-adrenergic signaling dampens the neuroinflammatory response following ischemic stroke and increases stroke size[J]. Journal of Neuroinflammation, 2019, 16(1): 112.
Alexandrova M L, Danovska M P. Cognitive impairment one year after ischemic stroke: predictorsand dynamics of significant determinants[J]. Turkish Journal of Medical Sciences, 2016, 46: 1366-1373.
Cui L, Lu P, Li S, et al. Relationship Among Homocysteine, Inflammation and Cognitive Impairment in Patients with Acute Ischemic Stroke and Transient Ischemic Attack[J]. Neuropsychiatric Disease and Treatment, 2021, Volume 17: 3607-3616.
Kim K Y, Shin K Y, Chang K A. Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis[J]. International Journal of Molecular Sciences, 2022, 23(2): 602.
Tanaka T, Narazaki M, Kishimoto T. IL-6 in Inflammation, Immunity, and Disease[J]. Cold Spring Harbor Perspectives in Biology, 2014, 6(10): a016295-a016295.
Darweesh S K L, Wolters F J, Ikram M A, et al. Inflammatory markers and the risk of dementia and Alzheimer’s disease: A meta‐analysis[J]. Alzheimer’s & Dementia, 2018, 14(11): 1450-1459.
Pusch G, Debrabant B, Molnar T, et al. Early Dynamics of P-selectin and Interleukin 6 Predicts Outcomes in Ischemic Stroke[J]. Journal of Stroke and Cerebrovascular Diseases, 2015, 24(8): 1938-1947.
Kulesh A, Drobakha V, Kuklina E, et al. Cytokine Response, Tract-Specific Fractional Anisotropy, and Brain Morphometry in Post-Stroke Cognitive Impairment[J]. Journal of Stroke and Cerebrovascular Diseases, 2018, 27(7): 1752-1759.
VanGilder R L, Davidov D M, Stinehart K R, et al. C-reactive protein and long-term ischemic stroke prognosis[J]. Journal of Clinical Neuroscience, 2014, 21(4): 547-553.
Zhang X, Bi X. Post-Stroke Cognitive Impairment: A Review Focusing on Molecular Biomarkers[J]. Journal of Molecular Neuroscience, 2020, 70(8): 1244-1254.
GuoJ, SuW, FangJ, et al. Elevated CRP at admission predicts post-stroke cognitive impairment in Han Chinese patients with intracranial arterial stenosis[J]. Neurological Research, 2018, 40(4): 292-296.
Petrone A B, Eisenman R D, Steele K N, et al. Temporal dynamics of peripheral neutrophil and lymphocytes following acute ischemic stroke[J]. Neurological Sciences, 2019, 40(9): 1877-1885.
Liu Y, Dong Y H, Lyu P Y, et al. Hypertension-Induced Cerebral Small Vessel Disease Leading to Cognitive Impairment[J]. Chinese Medical Journal, 2018, 131(5): 615-619.
Liu J H, Zhang Y J, Ma Q H, et al. Elevated blood neutrophil to lymphocyte ratio in older adults with cognitive impairment[J]. Archives of Gerontology and Geriatrics, 2020, 88: 104041.
Iadecola C. The Pathobiology of Vascular Dementia[J]. Neuron, 2013, 80(4): 844-866.
Bobińska K, Gałecka E, Szemraj J, et al. Is there a link between TNF gene expression and cognitive deficits in depression? [J]. Acta Biochimica Polonica, 1970, 64(1).
Cui G, Wang H, Li R, et al. Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke[J]. Journal of Neuroinflammation, 2012, 9(1): 235.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Ailin Yang, Fang Yu, Liu Yang
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
