Progress on Traditional Chinese Medicine Prevention and Treatment of Polycystic Ovary Syndrome based on PI3K/AKT Signaling Pathway

Abstract

Polycystic ovary syndrome (PCOS) is a multifactorial reproductive endocrine metabolism disorder, which is closely related to granulosa cell dysfunction, high androgen, insulin resistance, oxidative stress and cellular autophagy. Phosphatidylinositol 3-kinase/protein kinase B (phosphatidylinositol3-kinase/proteinkinaseB, PI3K/AKT) is the main pathway of intracellular signaling. In recent years, studies have confirmed that PI3K/AKT pathway participates in the repair of ovarian tissue damage and the regulation of glucose and lipid metabolism by regulating granulosa cell function, insulin resistance state, oxidative stress and autophagy. TCM has obvious advantages in the treatment of PCOS. One of the mechanisms of PCOS is the regulation of PI3K/AKT signaling pathway, but there are few systematic reviews and reviews of this field at home and abroad. Based on this, this paper summarizes the regulation mechanism of PI3K/AKT signaling pathway in PCOS in recent years and the role of TCM monomer and compound intervention in diseases, in order to provide theoretical basis for the basic and clinical research of PCOS.