Study on the Mechanism of Acupuncture and Moxibustion Regulating the Central Nervous System of Osteoarthritis
DOI:
https://doi.org/10.53469/jcmp.2024.06(07).02Keywords:
Osteoarthritis, Central nervous system mechanisms, Acupuncture and moxibustion analgesiaAbstract
OA is considered a non lethal chronic progressive disease with a particularly complex pathogenesis. Current treatment methods mainly aim to delay the progression of the disease, alleviate pain, and improve bone and joint functional activity. Arthritis pain is the most common cause of OA, which is not only related to pathological changes of bone and joint, but also involves complex neural mechanisms. Clarifying this point has guiding significance for the treatment of osteoarthritis. This article will describe the central nervous mechanism of acupuncture and moxibustion regulating chronic pain in OA.
References
van der Heijden RA, Oei EH, Bron EE, van Tiel J, van Veldhoven PL, Klein S, Verhaar JA, Krestin GP, Bierma-Zeinstra SM, van Middelkoop M. No Difference on Quantitative Magnetic Resonance Imaging in Patellofemoral Cartilage Composition Between Patients With Patellofemoral Pain and Healthy Controls. Am J Sports Med. 2016 May;44(5):1172-8. doi: 10. 1177/0363546516632507.
Mäntyselkä P, Kumpusalo E, Ahonen R, Kumpusalo A, Kauhanen J, Viinamäki H, Halonen P, Takala J. Pain as a reason to visit the doctor: a study in Finnish primary health care. Pain. 2001 Jan;89(2-3):175-180. doi: 10. 1016/s0304-3959(00)00361-4.
Haake M, Müller HH, Schade-Brittinger C, Basler HD, Schäfer H, Maier C, Endres HG, Trampisch HJ, Molsberger A. German Acupuncture Trials (GERAC) for chronic low back pain: randomized, multicenter, blinded, parallel-group trial with 3 groups. Arch Intern Med. 2007 Sep 24;167(17):1892-8. doi: 10. 1001/archinte. 167. 17. 1892. Erratum in: Arch Intern Med. 2007 Oct 22;167(19):2072.
Cummings M. Modellvorhaben Akupunktur--a summary of the ART, ARC and GERAC trials. Acupunct Med. 2009 Mar;27(1):26-30. doi: 10. 1136/aim. 2008. 000281.
Arendt-Nielsen L, Graven-Nielsen T. Central sensitization in fibromyalgia and other musculoskeletal disorders. Curr Pain Headache Rep. 2003 Oct;7(5):355-61. doi: 10. 1007/s11916-003-0034-0.
Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T. Sensitization in patients with painful knee osteoarthritis. Pain. 2010 Jun;149(3):573-581. doi: 10. 1016/j. pain. 2010. 04. 003.
Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011 Mar;152(3 Suppl): S2-S15. doi: 10. 1016/j. pain. 2010. 09. 030. Epub 2010 Oct 18.
Staud R. Evidence for shared pain mechanisms in osteoarthritis, low back pain, and fibromyalgia. Curr Rheumatol Rep. 2011 Dec;13(6):513-20. doi: 10. 1007/s11926-011-0206-6.
Mease PJ, Hanna S, Frakes EP, Altman RD. Pain mechanisms in osteoarthritis: understanding the role of central pain and current approaches to its treatment. J Rheumatol. 2011 Aug;38(8):1546-51. doi: 10. 3899/jrheum. 100759.
Lee YC, Nassikas NJ, Clauw DJ. The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia. Arthritis Res Ther. 2011 Apr 28;13(2):211. doi: 10. 1186/ar3306.
Ordeberg G. "Evidence of sensitization to pain in human os- teoarthritis, " in Pain in Osteoarthritis, ed. Felson DT, Schaible H. -G, editors[J]. Hoboken: Wiley Blackwell, 2009, 199-209.
Suokas AK, Walsh DA, McWilliams DF, Condon L, Moreton B, Wylde V, Arendt-Nielsen L, Zhang W. Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2012 Oct;20(10):1075-85. doi: 10. 1016/j. joca. 2012. 06. 009.
Adães S, Almeida L, Potes CS, Ferreira AR, Castro-Lopes JM, Ferreira-Gomes J, Neto FL. Glial activation in the collagenase model of nociception associated with osteoarthritis. Mol Pain. 2017 Jan;13:1744806916688219. doi: 10. 1177/1744806916688219. PMID: 28326927; PMCID: PMC5302176.
Mousseau M, Burma NE, Lee KY, Leduc-Pessah H, Kwok CHT, Reid AR, O'Brien M, Sagalajev B, Stratton JA, Patrick N, Stemkowski PL, Biernaskie J, Zamponi GW, Salo P, McDougall JJ, Prescott SA, Matyas JR, Trang T. Microglial pannexin-1 channel activation is a spinal determinant of joint pain. Sci Adv. 2018 Aug 8;4(8):eaas9846. doi: 10. 1126/sciadv. aas9846.
Havelin J, Imbert I, Cormier J, Allen J, Porreca F, King T. Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis. J Pain. 2016 Mar;17(3):374-82. doi: 10. 1016/j. jpain. 2015. 12. 001.
Liao X, Mao C, Wang Y, Zhang Q, Cao D, Seminowicz DA, Zhang M, Yang X. Brain gray matter alterations in Chinese patients with chronic knee osteoarthritis pain based on voxel-based morphometry. Medicine (Baltimore). 2018 Mar;97(12):e0145. doi: 10. 1097/MD. 0000000000010145.
Shi Aijun, Li Chunlei, Wu Yuan, et al. Local consistency study of resting state brain function in patients with chronic pain of knee osteoarthritis [J]. Journal of Localized Surgery,, 2017, 26(06):419-422.
Cottam WJ, Iwabuchi SJ, Drabek MM, Reckziegel D, Auer DP. Altered connectivity of the right anterior insula drives the pain connectome changes in chronic knee osteoarthritis. Pain. 2018 May;159(5):929-938. doi: 10. 1097/j. pain. 0000000000001209.
Ossipov MH, Dussor GO, Porreca F. Central modulation of pain. J Clin Invest. 2010 Nov;120(11):3779-87. doi: 10. 1172/JCI43766.
Li Z, Liu M, Lan L, Zeng F, Makris N, Liang Y, Guo T, Wu F, Gao Y, Dong M, Yang J, Li Y, Gong Q, Liang F, Kong J. Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment. Sci Rep. 2016 Feb 3;6:20298. doi: 10. 1038/srep20298.
Li Z, Zeng F, Yin T, Lan L, Makris N, Jorgenson K, Guo T, Wu F, Gao Y, Dong M, Liu M, Yang J, Li Y, Gong Q, Liang F, Kong J. Acupuncture modulates the abnormal brainstem activity in migraine without aura patients. Neuroimage Clin. 2017 May 22;15:367-375. doi: 10. 1016/j. nicl. 2017. 05. 013.
Chen X, Spaeth RB, Retzepi K, Ott D, Kong J. Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients. Sci Rep. 2014 Sep 26;4:6482. doi: 10. 1038/srep06482.
Chen X, Spaeth RB, Freeman SG, Scarborough DM, Hashmi JA, Wey HY, Egorova N, Vangel M, Mao J, Wasan AD, Edwards RR, Gollub RL, Kong J. The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients. Mol Pain. 2015 Oct 29;11:67. doi: 10. 1186/s12990-015-0071-9.
Egorova N, Gollub RL, Kong J. Repeated verum but not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain. Neuroimage Clin. 2015 Sep 25;9:430-5. doi: 10. 1016/j. nicl. 2015. 09. 012.
Tsai HY, Lin JG, Inoki R. Further evidence for possible analgesic mechanism of electroacupuncture: effects on neuropeptides and serotonergic neurons in rat spinal cord. Jpn J Pharmacol. 1989 Feb;49(2):181-5. doi: 10. 1254/jjp. 49. 181.
Perl ER. Ideas about pain, a historical view. Nat Rev Neurosci. 2007 Jan;8(1):71-80. doi: 10. 1038/nrn2042.
Lin JG, Chen WL. Acupuncture analgesia: a review of its mechanisms of actions. Am J Chin Med. 2008;36(4):635-45. doi: 10. 1142/S0192415X08006107.
Chen X, Spaeth RB, Retzepi K, Ott D, Kong J. Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients. Sci Rep. 2014 Sep 26;4:6482. doi: 10. 1038/srep06482.
Liu X. [The modulation of cerebral cortex and subcortical nuclei on NRM and their role in acupuncture analgesia]. Zhen Ci Yan Jiu. 1996;21(1):4-11. Chinese.
Millan MJ. Descending control of pain. Prog Neurobiol. 2002 Apr;66(6):355-474. doi: 10. 1016/s0301-0082(02)00009-6.
Niddam DM, Chan RC, Lee SH, Yeh TC, Hsieh JC. Central modulation of pain evoked from myofascial trigger point. Clin J Pain. 2007 Jun;23(5):440-8. doi: 10. 1097/AJP. 0b013e318058accb.
Guo ZL, Moazzami AR, Longhurst JC. Electroacupuncture induces c-Fos expression in the rostral ventrolateral medulla and periaqueductal gray in cats: relation to opioid containing neurons. Brain Res. 2004 Dec 24;1030(1):103-15. doi: 10. 1016/j. brainres. 2004. 09. 059.
Kim SK, Park JH, Bae SJ, Kim JH, Hwang BG, Min BI, Park DS, Na HS. Effects of electroacupuncture on cold allodynia in a rat model of neuropathic pain: mediation by spinal adrenergic and serotonergic receptors. Exp Neurol. 2005 Oct;195(2):430-6. doi: 10. 1016/j. expneurol. 2005. 06. 018.
Seo BK, Sung WS, Park YC, Baek YH. The electroacupuncture-induced analgesic effect mediated by 5-HT1, 5-HT3 receptor and muscarinic cholinergic receptors in rat model of collagenase-induced osteoarthritis. BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10. 1186/s12906-016-1204-z.
Chang FC, Tsai HY, Yu MC, Yi PL, Lin JG. The central serotonergic system mediates the analgesic effect of electroacupuncture on ZUSANLI (ST36) acupoints. J Biomed Sci. 2004 Mar-Apr;11(2):179-85. doi: 10. 1007/BF02256561. PMID: 14966368.
Liu Shiqiong, Du Xiaozheng, Qin Xiaoguang, et al. Study on the mechanism of central and peripheral analgesia in the treatment of rheumatoid arthritis with traditional "heat reinforcing acupuncture" [J]. Shanghai acupuncture and moxibustion Journal, 2006(11):36-39. DOI:10. 13460/j. issn. 1005-0957. 2006. 11. 024.
Chen Jin, Liu Guangpu, Tang Yong. The role of central and peripheral 5-HT and 5-HIAA in the post acupuncture analgesic effect [J]. Journal of Traditional Chinese Medicine, 2003(09):1446-1449. DOI:10. 13193/j. archtcm. 2003. 09. 36. chenj. 021.
Seo BK, Sung WS, Park YC, Baek YH. The electroacupuncture-induced analgesic effect mediated by 5-HT1, 5-HT3 receptor and muscarinic cholinergic receptors in rat model of collagenase-induced osteoarthritis. BMC Complement Altern Med. 2016 Jul 13;16:212. doi: 10. 1186/s12906-016-1204-z.
Eriksson SV, Lundeberg T, Lundeberg S. Interaction of diazepam and naloxone on acupuncture induced pain relief. Am J Chin Med. 1991;19(1):1-7. doi: 10. 1142/S0192415X91000028. PMID: 1654741.
Seo BK, Park DS, Baek YH. The analgesic effect of electroacupuncture on inflammatory pain in the rat model of collagenase-induced arthritis: mediation by opioidergic receptors. Rheumatol Int. 2013 May; 33(5):1177-83. doi: 10. 1007/s00296-012-2502-5.
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