Research Progress of Chinese Medicine in the Treatment of Influenza A in Children
DOI:
https://doi.org/10.53469/jcmp.2024.06(07).01Keywords:
Influenza A, Chinese medicineAbstract
Influenza A (H1N1) is an acute respiratory infection caused by the influenza virus subtype H1N1. Among the serious complications include severe pneumonia, acute respiratory distress syndrome, fulminant myocarditis and necrotizing encephalitis, the most serious of which may be life-threatening. The main treatment for influenza A in Western medicine is the use of antiviral drugs, but the phenomenon of drug resistance has emerged, and there are certain limitations in clinical application. Vaccine is an effective measure to prevent and control influenza virus, but in the face of mutating influenza virus, the developed vaccine gradually loses its protective effect, and the new vaccine is unable to control the influenza that occurs in the current season in a timely manner. The genetic characteristics of influenza viruses make vaccines lagging behind and easily induce resistance to some antiviral drugs. In addition, the antigenic drift of influenza viruses makes it difficult to develop vaccines and drugs. In recent years, traditional Chinese medicine (TCM) has shown good results in the treatment of influenza A through the four diagnostic methods of diagnosis and treatment, and the exploration of TCM treatment of influenza A has received more and more attention and has become a hot issue in current research. At present, a variety of formulas have been proved to be effective in the treatment of influenza A. The existence of TCM provides more diversified choices for the research and development of new antiviral drugs and the prevention and treatment of influenza pandemic in the future, and provides a new way of thinking and direction for the prevention and treatment of influenza A.
References
Dong Zongqi. Clinical features and diagnostic points of influenza in children[J]. Chinese Journal of Pediatrics, 2003, 41(1):3.
Ministry of Health. Diagnosis and treatment of A(H1N1) influenza (Version 3, 2009) [S/OL]. [2009–10–13]. http: // www. moh. gov. cn / publicfiles // business / htmlfiles / h1n1 / s106z8 /200912 /45261. html．
Dong Zongqi. Clinical characteristics of H1N1 influenza A in children[J]. Chinese Journal of Practical Pediatrics, 2010, 25(2): 81–82.
JAVANIAN M, BARARY M, GHEBREHEWET S, et al. A brief review of influenza virus infection [J]. J Med Virol, 2021, 93(8): 4638-46.
Hillenbrand K. Antiviral therapy for influenza infection[J]. Pediatr Rev, 2005, 26(11): 427-428.
Y Gu, Hsu A-C, Pang Z, et al. Role of the Innate Cytokine Storm Induced by the Influenza A Virus[J]. Viral Immunol, 2019, 32(6): 244-251.
Y Gu, Zuo X, Zhang S, et al. The Mechanism behind Influenza Virus Cytokine Storm[J]. Viruses, 2021, 13(7).
S Jin, Li Y, Pan R, et al. Characterizing and controlling the inflammatory network during influenza A virus infection[J]. Sci Rep, 2014, 43799.
N Sharma-Chawla, Sender V, Kershaw O, et al. Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation[J]. Infect Immun, 2016, 84(12): 3445-3457.
A Bahadoran, Lee S-H, Wang S-M, et al. Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors[J]. Front Microbiol, 2016, 71841.
J-R Tisoncik, Korth M-J, Simmons C-P, et al. Into the eye of the cytokine storm[J]. Microbiol Mol Biol Rev, 2012, 76(1): 16-32.
YUAN S, JIANG S C, ZHANG Z W, et al. Quantificationof Cytokine Storms During VirusInfections [J]. Front Immunol. 2021 May 17;12:659419.
MA Q, HUANG W, ZHAO J, et al. Liu Shen Wan inhibits influenza a virus and excessive virus-induced inflammatory response via suppression of TLR4/NF-κB signaling pathway in vitro and in vivo [J]. J Ethnopharmacol. 2020 Apr 24;252:112584.
Q Jiang, Li Z, Tao T, et al. TNF-alpha in Uveitis: From Bench to Clinic[J]. Front Pharmacol, 2021, 12740057.
K Romanowska-Prochnicka, Felis-Giemza A, Olesinska M, et al. The Role of TNF-alpha and Anti-TNF-alpha Agents during Preconception, Pregnancy, and Breastfeeding[J]. Int J Mol Sci, 2021, 22(6).
TANAKA T, NARAZAKI M, KISHIMOTO T. Interleukin (IL-6) Immunotherapy[J]. Cold Spring HarbPerspect Biol. 2018 Aug 1;10(8):a028456.
Mengru Yang, Yi Wang, Yimin Yue, et al. Traditional Chinese medicines as effective agents against influenza virus- induced pneumonia [J]. Biomed Pharmacother, 2022;153:113523.
Shi Yue, Shi Ren Bing, Liu Bin, et al. Studies on Antiviral Flavonoids in Yinqiaosan Powder[J]. China Journal of Chinese Materia Medica, 2001, 26(5): 320-323.
Chen Qiaomou, Huang Lijie, et al. Clinical Application and Pharmacological Experiment Study of Yingqiao Powder[J]. Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology, 2003,9(9):37-39.
Zhang Zhaoyan, Zhou Zhe. Clinical Applications and Experimental Researches of TCM Forum "Yin Qiao San" on Anti-influenza Virus [J]. Acta Chinese Medicine, 2015, 30(3):438-440
Sheng Dan, Li Jingbo, Liu Jin. Experimental study on anti-function of three decoctions of Xinwen Jiebiao on H1N1 of Influenza virus in rats[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2007, 16(1):25-27.
Li Xiaodong. Liquid chromatography-mass spectrometry analysis of chemical ingredients and its anti-inflammatory activity[D]. Zhejiang University of Technology, 2015.
Li Jingbo. Experimental study on the effect of three solution methods against influenza virus type 1[J]. New Chinese Medicine, 200436(1):78-79.
Feng Jinli, Wang Delong, et al. Comparison of functions new Elsholtzia drink and its drugs on anti-influenza A virus[J]. Journal of Hunan University of Chinese Medicine, 2010, 30(1):31-33.
TianBo Zhang, MengJie Xiao, Chun -Kwok Wong, et al. Sheng Jiang San, a traditional multi-herb formulation, exerts antiinfluenza effects in vitro and in vivo via neuraminidase inhibition and immune regulation. BMC Complementary and Alternative Medicine, 2018, 18(1):150-158.
Liu Mingjing. Experimental study of baicalin against influenza A virus in vitro[J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2015, 34(11):146-161.
Wang Fuke, Wan Qiaofeng, Gu Ligang, et al. Effect of baicalin on pathological improvment of the lung with H1N1 infection and its mechanism[J]. Lishizhen Medicine and Materia Medica Research, 2015, 26(1): 251-254.
Pang P, Zheng K, Wu S, et al. Baicalin downregulates RLRs signaling pathway to control influenza A virus infection and improve the prognosis. Evidence-Based Complementary and Alternative Medicine, 2018, 2018:4923062.
CHANG CH, CHANG YT, TSENG TH, et al. Mulberry leaf extract inhibit hepatocellular carcinoma cell proliferation via depressing lL-6 and TNF-alpha derived from adipocyte[J]. J Food Drug Anal, 2018, 26(3):1024-1032.
LI Li, DU Ya-wei, KOU Shuang, ZHAO Jing, et al. Bioinformatics Analysis on Effect of Lonicerae Japonicae Flos and Forsythiae Fructus on Immune Pathway of H1N1 Influenza A[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2017, 23(10): 201-204.
HUANG Zhi-sheng, YANG Bin, ZHANG Qing, SUN Jian, et al. Effect of baicalin combined with phillyrin on the gene expression of influenza A virus nucleoprotein[J]. Journal of Medical Postgraduates, 2018, 31(10):1033-1037.
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