Clinical Observation on the Efficacy of Modified Guipi Decoction in Treating Cognitive Dysfunction in Senile Dementia

Authors

  • Xiaomei Feng Guizhou University of Traditional Chinese Medicine, Guiyang 550002, Guizhou, China
  • Liping Cao Department of Neurology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, Guizhou, China

DOI:

https://doi.org/10.53469/jcmp.2025.07(03).46

Keywords:

Modified Guipi Decoction, Alzheimer’s disease, Cognitive dysfunction

Abstract

Objective: To observe the therapeutic effect of the modified Chinese herbal compound Guipi Decoction on cognitive dysfunction in elderly patients with Alzheimer’s disease. Methods: Eligible patients with Alzheimer’s disease and cognitive dysfunction were randomly divided into a treatment group and a control group. The control group received conventional Western medicine, while the treatment group received both conventional Western medicine and modified Guipi Decoction for 12 weeks. Cognitive function (MMSE, MoCA scores) and daily living ability (ADL score) were compared before and after treatment. Results: After treatment, the MMSE and MoCA scores in the treatment group were significantly higher than those in the control group, while the ADL score was significantly lower (P < 0.05). Conclusion: The combination of modified Guipi Decoction and conventional Western medicine effectively improved cognitive function and daily living ability in elderly patients with Alzheimer’s disease, demonstrating superior efficacy compared to Western medicine alone.

References

Ma Yifu, Lu Xin. Research progress on the mechanism of action of modern traditional Chinese medicine compound Huannaoyicong Fang in the treatment of elderly dementia[J]. Clinical Focus, 2024, 39 (08): 752-757.

Xi Chuanyue. A systematic review of traditional Chinese medicine compound therapy for mild cognitive impairment with amnesia [D]. Beijing University of Traditional Chinese Medicine, 2016.

Liu Yuan, Zhang Ying, Song Zhizhao. Progress in pharmacological research on the treatment of elderly dementia with traditional Chinese medicine compound preparations[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2014, 23 (11): 48-49.

Yan Hua. The effect and mechanism of early intervention of traditional Chinese medicine compound extract on cognitive function of APP transgenic mice [D]. Beijing University of Traditional Chinese Medicine, 2011.

Li Chunwei. Clinical Literature Study on the Treatment of Elderly Dementia with Traditional Chinese Medicine Compound [D]. Beijing University of Traditional Chinese Medicine, 2010.

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Published

2025-03-28

How to Cite

Feng, X., & Cao, L. (2025). Clinical Observation on the Efficacy of Modified Guipi Decoction in Treating Cognitive Dysfunction in Senile Dementia. Journal of Contemporary Medical Practice, 7(3), 232–234. https://doi.org/10.53469/jcmp.2025.07(03).46

Issue

Vol. 7 No. 3 (2025): JCMP-Volume 7 Issue 3

Section

Articles

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Copyright (c) 2025 Xiaomei Feng, Liping Cao

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This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.