Advances in the Theoretical Basis and Clinical Research of Acupuncture and Moxibustion in the Treatment of Rheumatoid Arthritis in Chinese and Western Medicine
DOI:
https://doi.org/10.53469/jcmp.2025.07(03).30Keywords:
Rheumatoid arthritis, Acupuncture, Integrated Chinese and Western medicine, Immunomodulation, Th17/Treg cellsAbstract
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and bone erosion. This paper elucidates the pathogenesis of RA from the perspective of integrating Chinese and Western medicine, and reveals the central role of acupuncture in the reconstruction of immune homeostasis through multi-target regulation. Studies have shown that acupuncture exerts its therapeutic effects by regulating Th17/Treg balance, inhibiting inflammatory factors (IL-17, TNF-α) and activating the HPA axis. Clinical practice has confirmed that characteristic therapies such as electro-acupuncture and fire-acupuncture combined with western medicine can synergistically improve joint symptoms. This article provides theoretical basis and practical path for the treatment of RA by combining Chinese and Western medicine.
References
Qiang Guo. Rheumatoid arthritis: pathological mechanisms and modern pharmacologictherapies [J]. Bone Research, 2018, 6(02):107-120.
LI ZixuanCalabresi E, Petrelli F, Bonifacio AF, et al. One year in review 2018: pathogenesis of rheumatoid arthritis [J]. Clinical & Experimental Rheumatology, 2018, 36(2):175-184.
Calabresi E, Petrelli F, Bonifacio AF, et al. One year in review 2018: pathogenesis of rheumatoid arthritis[J]. Clinical & Experimental Rheumatology, 2018, 36(2): 175-184.
HU Shuihan, QIAO Chenxi, YU Zongliang, et al. Overview of studies on the pathogenesis of rheumatoid arthritis[J]. World Digest of Recent Medical Information, 2019, 19(98):52-53.
Puravath A. T-cell large granular lymphocytic leukaemia in the context of rheumatoid arthritis[J]. The Lancet, 2018, 392(10154): 1071-1072.
Li J. Targeting NF-κB and TNF-α activation by electroacupuncture to suppress collagen-induced rheumatoid arthritis in model rats[J]. Alternative Therapies in Health and Medicine, 2015, 21(4):26-34.
Boissier MC. Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm [J]. Joint Bone Spine, 2008, 75(4):373-375.
Maseda D. Regulation of B lymphocytes and plasma cells by innate immune mechanisms and stromal cells in rheumatoid arthritis[J]. Expert Review of Clinical Immunology, 2014, 10(6):747-762.
Mahto A. Synovial B-Cells predict response/resistance to rituximab therapy in rheumatoid arthritis: preliminary results from a pilot study[J]. Rheumatology, 2014, 53(suppl_1):i107 .
Hernández-Flórez D, Valor L, Gallego A, et al. B-Cell activating factor (BAFF) binding receptors (BBR) on B cells: characterization in patients with rheumatoid arthritis (RA) receiving biological therapies: anti-TNF, anti-IL6R and anti-CTLA4: a longitudinal study[J]. Annals of the Rheumatic Diseases, 2014, 73(Suppl 2):902-903.
Yu JS, Zeng BY, Hsieh CL. Acupuncture stimulation and neuroendocrine regulation[J]. Int Rev Neurobiol, 2013, 111: 125-140.
Zhu J, Chen XY, Li LB, et al. Electroacupuncture attenuates collagen-induced arthritis in rats through vasoactive intestinal peptide signalling-dependent re-establishment of the regulatory T cell/T-helper 17 cell balance[J]. Acupunct Med, 2015, 33(4):305-311.
Zhou Tingting, Yan Mengzhen, Yu J, et al. Mechanisms of pain in rheumatoid arthritis[J]. Chemistry of Life, 2020, 40(7):1114-1120.
Ren Chaozhan, Du Xiaozheng, Fang Xiaoli. Analgesic effect of buccal pins on rabbits with rheumatoid arthritis and the influence of cerebrospinal fluid octapeptide cholecystokinin and β-endorphin[J]. Chinese Journal of Traditional Chinese Medicine Information, 2012, 19(12): 37-39.
CHEN Li, WANG Jian. Progress in the study of humoral regulation mechanism of acupuncture analgesia[J]. Shanghai Journal of Traditional Chinese Medicine, 2015, 49(11):91-93.
Li Jingjing, Sui Minghong, Lin Shiyu, et al. Determination of the effects of fire pins on 5-hydroxytryptamine, histamine and prostaglandin E2 in lesional tissues of rats with rheumatoid arthritis using microdialysis [J]. Journal of Jinan University (Natural Science and Medicine Edition), 2017, 38(4):314-321.
nes in different arthritic disorders[J]. Frontiers in Endocrinology, 2021, 12: 620920.
Zhang Y, Wang H, Gong YN, et al. Pathological pathway analysis in an experimental rheumatoid arthritis model and the tissue repair effect of acupuncture at ST36[J]. Frontiers in Immunology, 2023, 14: 1164157.
Fan ZZ. Research on the selection pattern of acupuncture points and acupuncture treatment method of rheumatoid arthritis [D]. North China University of Science and Technology, 2016.
Zhang Gao, et al. Literature-based study on the law of acupuncture point selection for rheumatoid arthritis[J]. Chinese Acupuncture and Moxibustion, 2017, 37(002): 221-224.
Yu Ying, et al. Analysis of the law of clinical selection of acupuncture points and medication in the treatment of rheumatoid arthritis with acupuncture and medication[J]. Jiangsu Traditional Chinese Medicine, 2016, 48(01): 73-75.
Liu SJ, Wang H, Liu ZH, et al. Observation on the efficacy of acupuncture combined with methotrexate in the treatment of rheumatoid arthritis and its effect on joint function and ESR and CRP levels[J]. Shanghai Journal of Acupuncture and Moxibustion, 2024, 43(1): 76-80.
YANG F M, GONG Y N, YU N N, et al. ST36 acupuncture alleviates the inflammation of adjuvant- induced arthritic rats by targeting monocyte/macrophage modulation [J]. Evid Based Complement Alternat Med, 2021, 2021:9430501.
Zhao Chen, Zhang Min, Zhu Yan, et al. Acupuncture modulation of PI3K/AKT/m TOR signaling pathway mediates autophagy to protect synovial tissues of knee joints in rats with adjuvant arthritis[J]. Acupuncture Research, 2021, 46(12):1016-1022.
LIN Gui-Ying, ZENG Hai-Cai. Clinical study of electroacupuncture combined with western medicine in the treatment of rheumatoid arthritis[J]. Shanghai Journal of Acupuncture and Moxibustion, 2021, 40(10): 1223-1227.
Wang Lei. Effect of electroacupuncture-assisted treatment of rheumatoid arthritis (liver-kidney yin deficiency type) and its influence on patients’ serum rheumatoid arthritis-related factor levels[J]. Chinese medicine clinical research, 2021, 13(25):62-64.
Susanna Zhang. Clinical observation of He’s fire needle for rheumatoid arthritis[J]. Guangming Traditional Chinese Medicine, 2019, 34(13):2037-2039.
Zheng YJ, Zhao XF. Research progress on the action mechanism and clinical application of fire needle therapy[J]. Journal of Practical Chinese Medicine, 2023, 39(9):1908-1912.
Zhou YF, Lin ZJ, Gong Y, et al. Effects of bee stings on Th17/Treg cell balance in rats with collagen-induced arthritis[J]. Chinese Journal of Traditional Chinese Medicine, 2021, 36(6):3549-3554.
CHEN Ying, WANG Shengxu, YANG Lu. Modulation of CD40-CD40L by bee stings in rats with rheumatoid arthritis[J]. Chinese Journal of Gerontology, 2023, 43(10): 2472-2475.
Duan Xiaorong, Zhang Fang, Deng Yaping, et al. Observations on the efficacy of bee-acupuncture six-yang meridian infusion points in the treatment of rheumatoid arthritis[J]. Shanghai Journal of Acupuncture and Moxibustion, 2021, 40(5):616-619.
Wan Bijiang, Xiao Qian, Xu Ying, et al. Effect of needle knife release on joint fluid MMP-3, MMP-9 and TIMP-1 in patients with elbow stiffness in rheumatoid arthritis[J]. Shanghai Journal of Acupuncture and Moxibustion, 2019, 38(1):89-93.
WANG Xiaoqing, WU Chunli, LI Luoyi, et al. Clinical study of minimally invasive needle knife microscopy technique in Chinese medicine for the treatment of early to mid-stage knee rheumatoid arthritis[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2019, 21(12):157-160.
Chen Lichuan, Duan Bo, Yu Zhao, et al. Acupuncture point burrowing affects inflammation level in rheumatoid arthritis through PD-1/OX40 signaling pathway[J]. Chinese Journal of Comparative Medicine, 2023, 33(10):8-14, 80.
LIU Xiaofei, ZHANG Bei, HE Fei. Efficacy of intradermal acupuncture combined with DMARDs drugs in the treatment of rheumatoid arthritis and its effect on joint mobility score and rheumatoid factor level[J]. Sichuan Traditional Chinese Medicine, 2022, 40(10):204-206.
Ruan Lingjuan, Yang Shiaohime, Chen Chunyan. Effect of warm acupuncture on joint ultrasound performance and serum CCL19 and ANGPTL2 in patients with rheumatoid arthritis[J]. Shanghai Journal of Acupuncture and Moxibustion, 2022, 41(1):77-82.
Cai GW, Li J, Li J. Effects of warm acupuncture on silent information regulatory factor 2-related enzyme 1 and nuclear transcription factor-κB protein in synovial tissue of rats with rheumatoid arthritis[J]. Acupuncture Research, 2017, 42(5):397-401.
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Copyright (c) 2025 Huifang Yue, Yali Ma, Lina Wang
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