Advances in Aging-related Secretory Phenotype-related Biomarkers in Osteoarthritis
DOI:
https://doi.org/10.53469/jcmp.2025.07(03).26Keywords:
Osteoarthritis, Aging-associated secretory phenotype, Biomarkers, Research progressAbstract
Objective: To summarize the research progress of aging-related secretory phenotype-related biomarkers and explore their value in the prevention and treatment of osteoarthritis. Methods: Through reviewing the literature, we summarized the research results on osteoarthritis aging-related secretory phenotype-related biomarkers in recent years, including their classification, current research status, and their value in clinical application. Results: Current research has identified a variety of biomarkers associated with the aging-related secretory phenotype of osteoarthritis, such as inflammatory factors, growth factors, matrix metalloproteinases, extracellular vesicles, and so on, and these biomarkers have a certain value of application in early diagnosis, disease monitoring, treatment monitoring, and prognostic assessment of OA. Conclusion: The study of aging-related secretory phenotype-related biomarkers provides certain guiding value for the prevention and treatment of osteoarthritis. However, there are still some problems and challenges in the current study, such as the specificity and sensitivity of the biomarkers need to be improved, and the sensitivity and specificity of the detection techniques need to be further optimized. In the future, further in-depth studies are needed to find more biomarkers with clinical application value to provide ideas and guidance for the prevention and treatment of chondrocyte aging and osteoarthritis.
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