Progress of Lead-induced Mechanisms of Nervous System-related Diseases in the Field of Molecular Biology
DOI:
https://doi.org/10.53469/jcmp.2025.07(03).19Keywords:
Lead, Neurotoxicity, Neuroinflammation, Oxidative stressAbstract
Lead is a toxic heavy metal associated with significant global health burdens, particularly in developing countries. This review synthesizes current molecular mechanisms of lead-induced neurotoxicity, focusing on oxidative stress, neuroinflammation, and the microbiota-gut-brain axis. Lead disrupts redox homeostasis, induces neuroinflammation via TLR4/MyD88-NF-κB signaling, and dysregulates gut microbiota, contributing to cognitive deficits and neurodegenerative risks. Emerging therapeutic strategies targeting these pathways offer novel insights for mitigating lead-related neurological disorders.
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Copyright (c) 2025 Qian Wang, Zengguo Wang, Jian Feng, Xiaofeng Xiong
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