Research Progress of Traditional Chinese Medicine Monomer in the Treatment of Psoriasis by Targeting Pyroptosis
DOI:
https://doi.org/10.53469/jcmp.2025.07(03).15Keywords:
Psoriasis, Pyroptosis, Chinese medicine monomerAbstract
As a chronic, recurrent and inflammatory skin disease, psoriasis is a difficult and urgent problem to be solved in clinic. In recent years, researchers have found that pyrodeath plays an important role in the occurrence and development of psoriasis, and psoriatic drugs targeting pyrodeath have also been extensively studied. This paper reviews the research on the treatment of psoriasis by targeting pyrodeath of traditional Chinese medicine monomers, in order to provide ideas for the development of new drugs for psoriasis
References
Griffiths C E M, Armstrong A W, Gudjonsson J E, et al. Psoriasis [J]. The Lancet, 2021, 397(10281): 1301-1315.
González-Parra S, Daudén E. Psoriasis y depresión: el papel de la inflamación [J]. Actas dermo-sifiliograficas, 2019, 110(1): 12-19.
Lian N, Chen Y, Chen S, et al. Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis [J]. Cell Death & Disease, 2023, 14(9): 595.
Rao Z, Zhu Y, Yang P, et al. Pyroptosis in inflammatory diseases and cancer [J]. Theranostics, 2022, 12(9): 4310.
Chen S, Mei S, Luo Y, et al. Gasdermin family: a promising therapeutic target for stroke [J]. Transl Stroke Res, 2018, 9 (6): 555-563.
Man SM, Kanneganti TD. Gasdermin D: the long-awaited executioner of pyroptosis [J]. Cell Ｒes, 2015, 25 (11): 1183-1184.
Rühl S, Broz P. Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K+ efflux [J]. European journal of immunology, 2015, 45(10): 2927-2936.
Yang D, He Y, Muñoz-Planillo R, et al. Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock [J]. Immunity, 2015, 43(5): 923-932.
An H, Heo J S, Kim P, et al. Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3 / GSDME in triple-negative breast cancer cells [J]. Cell death & disease, 2021, 12(2): 159.
Bhat A A, Thapa R, Afzal O, et al. The pyroptotic role of Caspase-3/GSDME signalling pathway among various cancer: A Review [J]. International journal of biological macromolecules, 2023, 242: 124832.
Sarhan J, Liu B C, Muendlein H I, et al. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection [J]. Proceedings of the National Academy of Sciences, 2018, 115(46): E10888-E10897.
Zheng Z, Deng W, Bai Y, et al. The lysosomal Rag-Ragulator complex licenses RIPK1–and caspase-8–mediated pyroptosis by Yersinia [J]. Science, 2021, 372(6549): eabg0269.
Chao K L, Kulakova L, Herzberg O. Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein [J]. Proceedings of the National Academy of Sciences, 2017, 114(7): E1128-E1137.
Zhou Z, He H, Wang K, et al. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells [J]. Science, 2020, 368(6494): eaaz7548.
Zhang Z, Zhang Y, **a S, et al. Gasdermin E suppresses tumour growth by activating anti-tumour immunity [J]. Nature, 2020, 579(7799): 415-420.
Su F, Xia Y, Huang M, et al. Expression of NLPＲ3 inpsoriasis Is associated with enhancement of interleukin-1b and caspase-1 [J]. Med Sci Monit, 2018, 24: 7909-7913
Feng S, Fox D, Man S M. Mechanisms of gasdermin family members in inflammasome signaling and cell death [J]. Journal of molecular biology, 2018, 430(18): 3068-3080.
Li Y, He Y, Yang F, et al. GSDME-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation [J]. British Journal of Dermatology, 2024: ljae179.
Ma J, Ji C, Sun Y, et al. Wogonin ameliorates the proliferation, inflammatory response, and pyroptosis in keratinocytes via NOD‐like receptor family pyrin domain containing 3/Caspase‐1/Gasdermin‐D pathway [J]. Immunity, Inflammation and Disease, 2024, 12(7): e1303.
Deng G, Chen W, Wang P, et al. Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice [J]. International Immunopharmacology, 2019, 74: 105682.
Li J, Yan W, Ren F, et al. Tectorigenin inhibits inflammation in keratinocytes by inhibition of NLRP3 inflammasome regulated by the TLR4/NF-κB pathway [J]. Allergologia et immunopathologia, 2023, 51(2): 82-89.
Zhou M W, Jiang R H, Kim K D, et al. Rosmarinic acid inhibits poly (I: C)-induced inflammatory reaction of epidermal keratinocytes [J]. Life sciences, 2016, 155: 189-194.
Tang L, Li T, Zhang B, et al. Punicalagin alleviates psoriasis by inhibiting NF-κB-mediated IL-1β transcription and caspase-1-regulated IL-1β secretion [J]. Frontiers in Pharmacology, 2022, 13: 817526.
Mao J, Ma X, Zhu J, et al. Ginsenoside Rg1 ameliorates psoriasis‐like skin lesions by suppressing proliferation and NLRP3 inflammasomes in keratinocytes [J]. Journal of Food Biochemistry, 2022, 46(5): e14053.
Choi M R, Choi D K, Sohn K C, et al. Inhibitory effect of Paeonia lactiflora Pallas extract (PE) on poly (I: C)-induced immune response of epidermal keratinocytes [J]. International Journal of Clinical and Experimental Pathology, 2015, 8(5): 5236.
Hu Jian. The expression of NLRP3 inflammasome in imiquimod induced mouse psoriasis like model and the effect of mustard seed on it [D]. Chinese People's Liberation Army Medical College, 2013.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Qin Sun, Xiaoning Yan
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
