Application of the Method of Promoting Blood Circulation and Removing Blood Stasis in Precancerous Lesions of Gastric Cancer
DOI:
https://doi.org/10.53469/jcmp.2025.07(02).25Keywords:
Gastric cancer, Gastric precancerous lesions, Promote blood circulation and remove blood stasis, TumorAbstract
Objective Precancerous lesions are the main risk factors leading to gastric cancer. Therefore, active intervention will help to reduce the incidence rate of gastric cancer. According to the theory of “blood stasis syndrome” in traditional Chinese medicine, the use of the “promoting blood circulation and removing blood stasis” treatment method has achieved good therapeutic effects in the diagnosis and treatment of precancerous lesions of gastric cancer. The method of promoting blood circulation and removing blood stasis includes promoting qi and blood circulation, nourishing yin and blood circulation, detoxifying and activating blood circulation, dispelling dampness and activating blood circulation, etc. Its mechanism of action is to prevent gastric mucosal atrophy, reverse intestinal metaplasia, cut off the process of epithelial neoplasia, inhibit new blood vessel formation, inhibit cancer cell growth, regulate inflammatory factors, delay disease progression, inhibit cell proliferation, and prevent cancer cell growth.
References
Wang Junfeng, Han Ting, Wu Jian Analysis of risk factors for postoperative gastric paralysis in elderly patients with gastric cancer [J]. Chinese Journal of Practical Diagnosis and Treatment, 2014, 28 (12): 1196-1197.
Li Mengying, Wang Yaoqun, Sun Mengyu, etc Identification of co expression network analysis of prognostic genes related to immune cell infiltration in gastric cancer [J]. Chinese Journal of General Surgery, 2021, 30 (04): 438-448.
National Clinical Research Center for Digestive Diseases (Shanghai), National Alliance of Digestive Early Cancer Prevention and Treatment Centers, Helicobacter pylori Group of Digestive Disease Branch of Chinese Medical Association, etc Expert consensus on management strategies for precancerous status and precancerous lesions of gastric mucosa in China (2020) [J]. Chinese Journal of Gastroenterology, 2020, 40 (11): 731-741.
Shi Weiguo, Ying Huana, Guo Ganhua The histological and IL-10/IL-17A effects of modified Huangqi Jianzhong decoction combined with Xilebao on gastric precancerous lesions of Taiyin deficiency cold type [J]. Chinese Journal of Integrative Gastroenterology, 2017, 25 (11): 815-819.
Zhang Xuan, Sun Dazhi, Qin Zhifeng, etc Study on the intervention of Xiaotan and Weifang on NF - κ B pathway in rats with precancerous lesions of gastric cancer [J]. Chinese Journal of Traditional Chinese Medicine, 2017, 35 (05): 1088-1090.
Zhang Taikun, Zhang Yan, Zheng Min, etc The effect of Xiaowei Tang on the therapeutic efficacy and COX-2 expression in precancerous lesions of gastric cancer through syndrome differentiation and modification [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 36 (08): 1986-1989.
Chen Jiabin, Xu Guoshu, Chen Wei, etc The clinical implications of the “Jin Kui Yao Lue” blood stasis treatment method for improving the hypercoagulable state of malignant tumors [J]. Chinese Journal of Oncology, 2019,1 (05): 1-5.
Cong Hongxia, Wang Shuai, Liang Junwei, and others Ideas and methods for the diagnosis and treatment of precancerous lesions of gastric cancer based on the theory of deficiency, stasis, and toxin [J]. Chinese Journal of Clinical Medicine, 2021, 33 (11): 2047-2050.
Wang Ping, Shi Bin, Wen Yandong, etc Research on the Construction of a Risk Prediction Model for Gastric Precancerous Lesions Based on Disease and Syndrome [J]. Chinese Journal of Integrated Traditional Chinese and Western Medicine, 2018, 38 (07): 773-778.
Huang Yuancheng, Huang Chaoyuan, Liang Huaifeng, etc Literature study on the distribution patterns of syndromes and syndrome elements in chronic non atrophic gastritis and chronic atrophic gastritis [J]. Journal of Traditional Chinese Medicine, 2019, 60 (16): 1417-1422.
Zhang Yang, Liu Sha, Wu Yuan, etc Research on the treatment of precancerous lesions of gastric cancer with the method of promoting blood circulation and removing blood stasis [J]. Chinese Journal of Basic Chinese Medicine, 2022, 28 (09): 1535-1538.
Liu Ju, Jin Zhenyu, Xu Qianfei, etc Discussion on the treatment of gastroesophageal reflux disease from the perspective of stomach regulation and descending [J]. Shanxi Traditional Chinese Medicine, 2022, 38 (09): 1-3.
Jia Lu, Jiang Jing, Xiao Yalin, etc The theoretical connotation of stomach qi in Huangdi Neijing and its guiding role in traditional Chinese medicine nursing [J]. Journal of Hunan University of Traditional Chinese Medicine, 2023, 43 (10): 1902-1905.
Zhang Zhengbo Preliminary Study on the Treatment of Chronic Atrophic Gastritis with the Method of Tonifying Qi, Clearing Heat and Activating Blood Circulation [J]. Guangming Traditional Chinese Medicine, 2016, 31 (18): 2753-2755.
Cheng Chaochao, Lei Wei, Liu Dongmei Turbidity, toxicity, blood stasis and the occurrence of chronic atrophic gastritis [J]. Henan Traditional Chinese Medicine, 2009, 29 (08): 766-767.
Song Zhen, Liu Dongmei, Wang Deyun Toxic damage to the gastric meridian and chronic atrophic gastritis [J]. Shanxi Traditional Chinese Medicine, 2014, 30 (02): 1-3.
Wang Wei, Liu Dongmei, Yuan Fang A new approach to treating precancerous lesions of chronic atrophic gastritis from the perspective of “toxicity” [J]. Jiangsu Traditional Chinese Medicine, 2016, 48 (03): 12-14.
Zhong Feng, Gu Jian, Zhang Liangliang, etc Modern research progress on the pharmacological effects of Curcuma zedoaria [J]. Chinese Folk Medicine, 2010,19 (13): 67-68.
Du Yanru, Liu Qiquan, Wang Zhikun, etc Detoxification and blood circulation therapy for 66 cases of precancerous lesions of gastric cancer [J]. Journal of Traditional Chinese Medicine, 2006 (01): 30.
Xue Hong, Huang Yingzhi Preliminary exploration of the concept of “Yin deficiency” in the “Neijing” [J]. Journal of Chengdu University of Traditional Chinese Medicine, 1999 (03): 2-4.
Jia Shengxi, Xia Qiumin, Wei Guolan, etc The effect of nourishing yin and promoting blood circulation formula on changes and outcomes of intestinal microbiota in precancerous lesions of gastric cancer [J]. New Traditional Chinese Medicine, 2019, 51 (05): 154-156.
Luo Kaili, Li Hui, Hua Yongzhi, etc Experience in treating precancerous lesions of gastric cancer from the perspective of dampness and stasis [J]. Global Journal of Traditional Chinese Medicine, 2021,14 (05): 939-941.
Wang Yuxian, Zhou Qiang, Zhang Shengsheng Analysis of the treatment of spleen and stomach diseases from the perspective of blood stasis [J]. Chinese Journal of Integrated Traditional Chinese and Western Medicine Digestive Medicine, 2018, 26 (07): 630-632.
Chu Juanhong, Ye Qian Overview of Pharmacology and Clinical Research of Coix Seed [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2008 (04): 159-160.
Wang Yihui, Chen Wanzhen, Zhu Fangshi Clinical research progress on the treatment of precancerous lesions of gastric cancer with the method of promoting blood circulation and removing blood stasis [J]. Chinese Medical Innovation, 2019,16 (13): 169-172.
Zhang Hongting The effect of invigorating spleen and qi, promoting blood circulation and removing blood stasis methods on symptom improvement and hemorheology in patients with chronic atrophic gastritis [J]. Inner Mongolia Traditional Chinese Medicine, 2023, 42 (06): 83-84.
She Rongrong, Guo Jinwei, Ge Huinan Clinical Observation on the Treatment of 25 Cases of Chronic Atrophic Gastritis of Qi Deficiency and Blood Stasis Type with Modified Yiqi Huoxue Tongluo Formula [J]. Hunan Journal of Traditional Chinese Medicine, 2023, 39 (02): 8-12.
Cai Tiantian, Pan Huafeng, Zhang Chengzhe, etc Study on the protective effect of Astragaloside IV on gastric mucosal injury in rats with precancerous lesions of gastric cancer [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 33 (09): 4066-4070.
Wu Futing Observation of the therapeutic effect of Yiqi Huayu Jiedu method on precancerous lesions of atrophic gastritis and its impact on EGF [D]. Anhui University of Traditional Chinese Medicine, 2019.
Zhang Yang, Liu Sha, Wu Yuan, etc Research on the treatment of precancerous lesions of gastric cancer with the method of promoting blood circulation and removing blood stasis [J]. Chinese Journal of Basic Chinese Medicine, 2022, 28 (09): 1535-1538.
Li Tao, Sun Caixing Molecular regulatory mechanism of tumor angiogenesis [J]. Chinese Journal of Oncology, 2014, 23 (01): 44-48.
Wang Yinping, Zou Yihai, Pan Huafeng, etc The relationship between the effect of promoting blood circulation and removing blood stasis in the prevention and treatment of gastric cancer and anti angiogenesis [J]. Chinese Journal of Integrative Gastroenterology, 2005 (03): 187-189.
Huang Yulun, Zhou Youxin, Zhou Dai, etc Experimental Study on the Inhibition of Angiogenesis by Triptolide [J]. Chinese Journal of Oncology, 2003 (05): 17-20.
Zhou Youxin, Sun Chengfa, Xu Qinian, etc In vitro study on the inhibition of vascular endothelial cell line proliferation by Triptolide [J]. Journal of Practical Cancer, 2004 (06): 564-566.
Yu Chunyue, Li Yicong, Su Zeqi, and others The effect of Manpi Xiao on the expression levels of serum inflammatory markers IL-1 β, IL-6, and TNF - α in rats with chronic atrophic gastritis [J]. Chinese Journal of Traditional Chinese Medicine, 2019, 34 (05): 1979-1983.
Hao Tingting, Ma Xiaopeng, Wen Yanli, etc Study on the serum levels of TNF - α, IL-8, and VEGF in patients with chronic gastritis infected with Helicobacter pylori and their correlation with the severity of gastritis [J]. Journal of Gastroenterology and Hepatology, 2016, 25 (07): 769-772.
Zheng Yi, Liu Yanmin, Chen Zhitao, etc Expression and clinical significance of tumor necrosis factor - α in gastric cancer and precancerous lesions infected with Helicobacter pylori [J]. Journal of Clinical Internal Medicine, 2020, 37 (10): 718-720.
Dai Minglong, Zhang Suoshan Study on the therapeutic effect of Huayu Jiedu Tongluo Formula on gastric collateral stasis toxin type precancerous lesions and its impact on the expression of inflammatory factors, COX-2, PGI, and G-17 in patients [J]. Sichuan Traditional Chinese Medicine, 2023, 41 (01): 118-122.
Hao Xurui, Li Na, Bai Haiyan, etc Experience of Traditional Chinese Medicine Master Li Diangui in Treating Chronic Atrophic Gastritis with Intestinal Epithelial metaplasia Using Insect Drugs [J]. Chinese Journal of Traditional Chinese Medicine, 2020, 35 (03): 1236-1239.
Liu Wenhu, Yuan Jiangbei, Zhang Fan, Chang Jinxia Curcumin inhibits the proliferation, migration, and invasion of gastric cancer cells through the Wnt3a/β - catenin/EMT signaling pathway [J]. Chinese Journal of Traditional Chinese Medicine, 2019, 44 (14): 3107-3115.
Zhang Qi, He Longxi, Zheng Xin, etc Research progress on the anti-tumor effect of curcumin [J]. West China Pharmaceutical Journal, 2023, 38 (04): 473-476.
Ji Yi, Wu Mianhua Research progress on chemical composition and anti-tumor mechanism of Shanci mushroom [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 36 (03): 596-598.
Niu Shurui, Shi Yun, Yang Xin, etc Research progress on the anti-tumor effects of chemical components in Scutellaria barbata [J]. Chinese Pharmacy, 2021, 32 (15): 1915-1920.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Shuolin Shang, Kai Wang
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
