Advances in Tissue Engineering for the Treatment of Urethral Stricture

Authors

  • Xiao Tan Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China; Department of Urology, Tangdu Hospital, Air Force Medical University, Xi'an 710038, Shaanxi, China
  • Xiaoyong Gong Department of Urology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi, China
  • Bo Zhang Department of Urology, Tangdu Hospital, Air Force Medical University, Xi'an 710038, Shaanxi, China

DOI:

https://doi.org/10.53469/jcmp.2025.07(02).22

Keywords:

Urethral stricture, Tissue engineering, Stent material, Seed cells

Abstract

Urethral stricture is a common disease of the urinary system, mainly caused by trauma, inflammation, iatrogenic injury and other factors, which can lead to dysuria, urinary retention and even renal function impairment, seriously affecting the quality of life of patients. Traditional treatments such as urethral dilatation and urethroplasty have limitations, including a high recurrence rate, many complications, and a lack of graft. Recent rapid development in tissue engineering techniques has provided a new direction for the repair of urethral strictures. This review summarizes the progress of tissue engineering in the treatment of urethral strictures, including the application of scaffold materials, seed cells, bioactive factors, and explores the challenges and prospects of future development.

References

Luo H, Lou K C, Xie L Y, et al. Pharmacotherapy of urethral stricture[J]. Asian Journal of Andrology, 2024, 26(1): 1-9.

Abbasi B, Shaw N M, Lui J L, et al. Posterior urethral stenosis: a comparative review of the guidelines[J]. World Journal of Urology, 2022, 40(11): 2591-2600.

Tritschler S, Roosen A, Füllhase C, et al. Urethral stricture: etiology, investigation and treatments. Dtsch Arztebl Int. 2013; 110:220–6.

Sun H, Zhao Z, Meng L, et al. Research advancement of tissue engineering in urology[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(8): 1306.

Atala A, Koh C. Applications of tissue engineering in the genitourinary tract[J]. Expert review of medical devices, 2005, 2(1): 119-126.

Naud E, Rourke K. Recent trends and advances in anterior urethroplasty[J]. Urologic Clinics, 2022, 49(3): 371-382.

Barbagli G, Lazzeri M. Surgical treatment of anterior urethral stricture diseases: brief overview[J]. International braz j urol, 2007, 33: 461-469.

Luo H, Lou K C, Xie L Y, et al. Pharmacotherapy of urethral stricture[J]. Asian Journal of Andrology, 2024, 26(1): 1-9.

Raheem OA, Buckley JC. Adjunctive maneuvers to treat urethral stricture: a review of the world literature. Transl Androl Urol. 2014;3(2):170-178.

Lumen N, Campos-Juanatey F, Greenwell T, et al. European Association of Urology Guidelines on Urethral Stricture Disease (Part 1): Management of Male Urethral Stricture Disease. Eur Urol. 2021; 80(2): 190-200.

Akpayak IC, Shuaibu SI, Ofoha CG, et al. Dorsal onlay buccal mucosa graft urethroplasty for bulbar urethral stricture: a single centre experience. Pan Afr Med J 2020;36:305.

Horiguchi A. Substitution urethroplasty using oral mucosa graft for male anterior urethral stricture disease: Current topics and reviews. Int J Urol 2017; 24(7):493–503.

Sinha R J, Singh V, Sankhwar S N, et al. Donor site morbidity in oral mucosa graft urethroplasty: implications of tobacco consumption[J]. BMC urology. 2009, 9: 1-7.

Thomas W. Gilbert, Tiffany L. Sellaro, Stephen F. Badylak, et al. Decellularization of tissues and organs[J]. Biomaterials, 2006, 27(19):3675-3683.

Chen, F., Yoo, J. J., et al. Acellular collagen matrix as a possible "off the shelf" biomaterial for urethral repair. Urology, 2010, 54(3), 407-410.

Badylak, S. F. The extracellular matrix as a scaffold for tissue reconstruction. Seminars in Cell & Developmental Biology, 2002, 13(5), 377-383.

Rashidi H, Yang J, Shakesheff K M. Surface engineering of synthetic polymer materials for tissue engineering and regenerative medicine applications[J]. Biomaterials science, 2014, 2(10): 1318-1331.

Wei L, Chang H, Wang Y, et al. A gelatin/ collagen/ polycaprolactone scaffold for skin regeneration. PeerJ 7:e6358.

Atala, A., Bauer, S. B., et al. Tissue-engineered autologous bladders for patients needing cystoplasty. The Lancet, 2006, 367(9518), 1241-1246.

Yu, J., Hu, K., Smuga-Otto, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science, 318(5858), 1917-1920.

Jia W, Tang H, Wu J, et al. Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model[J]. Biomaterials, 2015, 69: 45-55.

Zhu, W., Masood, F., O'Brien, J., et al. Highly aligned nanocomposite scaffolds by electrospinning and electrospraying for neural tissue regeneration. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016;12(3), 693-704.

Bhattacharjee G, Gohil N, Khambhati K, et al. Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications[J]. Journal of Controlled Release, 2022, 343: 703-723.

Booth D, Afshari R, Ghovvati M, et al. Advances in 3D bioprinting for urethral tissue reconstruction. Trends Biotechnol. 2024;42(5):544-559.

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Published

2025-02-28

How to Cite

Tan, X., Gong, X., & Zhang, B. (2025). Advances in Tissue Engineering for the Treatment of Urethral Stricture. Journal of Contemporary Medical Practice, 7(2), 114–117. https://doi.org/10.53469/jcmp.2025.07(02).22