Current Research on the Application of Xuefu Zhuyu Decoction and Its Modifications in the Treatment of Lung Cancer
DOI:
https://doi.org/10.53469/jcmp.2024.06(12).40Keywords:
Xuefu Zhuyu Decoction, Lung cancer, Mechanisms of action, Tumor mass, ReviewAbstract
Xuefu Zhuyu Decoction is a representative formula for treating "blood stasis syndrome" established by Wang Qingren in the Qing Dynasty. The formula consists of peach kernel, safflower, angelica, rehmannia, achyranthes, ligusticum, platycodon, red peony root, bitter orange, licorice, and bupleurum. Its primary therapeutic effects include activating blood circulation, resolving blood stasis, promoting qi flow, and alleviating pain. Xuefu Zhuyu Decoction and its modified versions have been widely used in modern clinical practice. This article summarizes and analyzes recent research on the application of Xuefu Zhuyu Decoction and its modifications in the treatment of lung cancer and related diseases. The review focuses on the mechanisms of action and clinical efficacy of Xuefu Zhuyu Decoction and its modifications in treating lung cancer and associated conditions.
References
Association OncologySocietyofChineseMedical, House ChineseMedicalAssociationPublishing. Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2023 edition) [J]. Natl Med J China, 2023, 103(27): 539-574.
Dacheng PANG, Shuo ZHANG, Tian TIAN, et al. Traditional Chinese Medicine Pathogenesis of the Formation and Metastasis of Lung Cancer Based on the Theory of “Yang Transforming Qi and Yin Constituting Form” [J]. World Chinese Medicine, 2023, 18(19): 2772-2776.
Junhua Gu, Jiaxiang Liu. The Core and Application of Professor Liu Jiaxiang's "Fuzheng Zhiliao" Theory for Cancer Treatment [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2017, 37(4): 495-499.
Huijuan Cui, Chao Zou, Hongyan Wang. Professor ZHANG Daizhao' s Knowledge of the Pathogenesis of Lung Cancer Based on Data Mining Technology [J]. Journal of Traditional Chinese Medicine, 2014, 55(2): 114-117.
Weijun ZHANG, Jianchun HOU, Yan WANG, et al. LU Zhizheng's Experiences in Treating Lung Cancer with Yifei Huaji Decoction [J]. Journal of Traditional Chinese Medicine, 2018, 59(4): 289-291.
Shixian Chen, Lixia Yuan, Yuqin Qiu, et al. The relationship between lung cancer and physical fitness [J]. Journal of Changchun University of Traditional Chinese Medicine, 2014, 30(1): 62-63.
Tao WANG, Xiaojiang HAN, Yanyi LI. Research Progress on Pharmacological Mechanism of Xuefu Zhuyu Decoction [J]. Journal of Shangluo University, 2022, 36(4): 16-22.
Qing-meng LI, Xiao-li LI, Jun SHAO, et al. Xuefu Zhuyu Tang and Derived Formulas [J]. World Journal of Integrated Traditional and Western Medicine, 2016, 11(6): 859-862.
Bi-chang LIAO, Li-hua ZOU, Hui LI. Effects of Xuefu Zhuyu Capsules Combined with Chemotherapy on Treatment and Coagulation Indexes in Patients with Mid-advanced Small Cell Lung Cancer [J]. Chinese Journal of Information on Traditional Chinese Medicine, 2015, 22(9): 26-29.
Hong Zhao, Jian Zhang. Discussion on the etiology and pathogenesis of lung cancer from "deficiency, phlegm, blood stasis, and toxin" [J]. Medical Innovation of China, 2013, 10(19): 159-161.
Lingling DAI, Dongmei CHEN, Shaomei ZHOU, et al. “Two-stage Three-step Method” Adjuvant Therapy in the Prevention and Treatment of Adverse Reactions of Chemotherapy in Colorectal Cancer [J]. Journal of Traditional Chinese Medicine, 2014, 60(11): 982-985.
Xinmei Qiao, Jinling Zhao. Observation on the Curative Effect of Xuefu Zhuyu Decoction Combined with Chemotherapy in the Treatment of 40 Cases of Small Cell Lung Cancer with Stasis Obstructing Lung Collaterals Syndrome [J]. Journal of New Chinese Medicine, 2013, 45(2): 55-56.
Qiang Dong, Guiqin Liu, Jianxin Liu, et al. Clinical Study on the Treatment of Middle and Advanced Small Cell Lung Cancer with Modified Xuefu Zhuyu Decoction [J]. Henan Traditional Chinese Medicine, 2014, 34(9): 1758-1760.
Xifeng Zhang, Xinxin Wang. Observation on the short-term efficacy of Xuefu Zhuyu Decoction combined with EP chemotherapy in the treatment of small cell lung cancer with blood stasis and lung collaterals syndrome [J]. Asia-Pacific Traditional Medicine, 2018, 14(1): 202-204.
Junming Xu, Xuefeng Cui, Ranran Li. Clinical Study on the Treatment of Locally Advanced Non-small Cell Lung Cancer with Xuefu Zhuyu Decoction Plus or Minus Combined with Radiotherapy and Chemotherapy [J]. Nei Mongol Journal of Traditional Chinese Medicine, 2018, 37(7): 64-65.
Heng Yao, Dejiao Yao. Modified Xuefu Zhuyu Decoction Combined with Chemotherapy in the Treatment of 45 Cases of Qi Stagnation and Blood Stasis Type Middle and Advanced Non Small Cell Lung Cancer [J]. Hunan Journal of Traditional Chinese Medicine, 2021, 37(11): 57-60.
Xiaoyan GU, Jinfang YANG, Huaqin XIE, et al. Effect of Xuefu Zhuyu Capsule on Prevention of PICC Related Venous Thrombosis in Patients with Advanced Lung Cancer Undergoing Chemotherapy [J]. Jilin Journal of Chinese Medicine, 2020, 40(2): 219-221+226.
Alexander N.Hanania WalkerMainwaring Yohannes T. Ghebre Nicola A. Hanania MichelleLudwig. Radiation-Induced Lung Injury [J]. Chest, 2019, 156: 150-162.
Fangchu Sun, Chunqiu Liu, Qiong Wu, et al. Clinical Study on the Effect of Xuefu Zhuyu Capsule on Radiation-induced Lung Injury and Serum TGF-β_1 in Patients with Lung Cancer [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2017, 26(12): 1317-1319.
Qiong Wu, Haiyang Ma, Zhiwu Wang, et al. Inhibitory Effect of Activating Blood and Resolving Stasis Method on Pulmonary Fibrosis after Radiotherapy for Lung Cancer [J]. Chinese Journal of Clinical Research, 2017, 30(9): 1261-1263.
Qiao Zheng, Tiecheng Zhou, Shengxia Xiang. Clinical Study of Xuefu Zhuyu Decoction in the Treatment of Pain from Advanced Lung Cancer with Yuxuezuluo Syndrome [J]. Pharmacology and Clinics of Chinese Materia Medica, 2022, 38(2): 195-198.
Lin TIAN, Shengnan BI, Mengzhu CHEN, et al. Research on the Mechanism of Xuefu Zhuyu Decoction in the Treatment of NSCLC Based on Network Pharmacology [J]. Western Journal of Traditional Chinese Medicine, 2022, 35(1): 21-28.
Xu XU, Encun HOU, Jiahui XIONG, et al. Mechanism of Xuefu Zhuyu Tang in Treating Advanced Lung Cancer of Qi-stagnation Blood-stasis Pattern Based on Network Pharmacology [J]. Western Journal of Traditional Chinese Medicine, 2022, 35(9): 32-45.
Lihuai Wang, Hong Zhang, Yinhui Sun, et al. The inhibitory effect of the Xuefu Zhuyu decoction on the growth of non-small cell lung cancer cells based on Wnt signaling pathway [J]. Clinical Journal of Chinese Medicine, 2022, 14(1): 58-60.
Lihuai WANG, Yinhui SUN, Lingxiong ZHANG, et al. Effect of Xuefu Zhuyu Decoction on the expression of GSK-3β and β-catenin in tumor-bearing mice with non-small cell lung cancer [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2022, 31(5): 603-607.
Lihuai WANG, Yinhui SUN, Lingxiong ZHANG, et al. Efficacy of Xuefu Zhuyu decoction in EGFR-TKI-Acquired resistance of non-small cell lung carcinoma based on the Wnt/β-catenin signaling pathway [J]. Shaanxi Journal of Traditional Chinese Medicine, 2022, 43(4): 427-431.
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